When Your CML Treatment Stops Working: Find Answers with BCR-ABL1 Mutation Analysis
We understand the worry and frustration when your chronic myeloid leukemia (CML) treatment begins to lose effectiveness. That moment when you realise your medication isn’t working as well as it used to can be overwhelming. Our BCR-ABL1 Kinase Domain Mutation Analysis IRMA test provides the clarity you need to understand why treatment resistance is occurring and what steps to take next.
Understanding Your BCR-ABL1 Mutation Analysis
Think of this test as a detective investigating why your CML treatment might be losing its power. The BCR-ABL1 gene plays a crucial role in CML, and sometimes it develops mutations that make medications less effective. Our advanced IRMA analysis identifies these specific genetic changes, giving your oncologist the information needed to adjust your treatment plan effectively.
Using sophisticated Sanger Sequencing technology, we examine the genetic blueprint of your cancer cells to pinpoint exactly which mutations are causing treatment resistance. This isn’t just another test – it’s a roadmap to more effective cancer management.
Who Should Consider This Essential Analysis?
This test becomes crucial when you notice:
- Your CML medication isn’t controlling your blood counts as effectively
- You’re experiencing unexpected side effects or treatment complications
- Your oncologist mentions concerns about treatment resistance
- You’ve had a recent increase in BCR-ABL1 levels despite ongoing treatment
- Your treatment plan needs adjustment due to changing response patterns
If you’re in Johannesburg, Cape Town, Durban, or anywhere in South Africa and facing these challenges, this analysis provides the answers you need.
Why This Analysis Matters for Your Health Journey
Early detection of treatment resistance can significantly impact your CML management:
- Personalised Treatment: Identify the right medication for your specific mutation
- Time-Saving: Avoid months of ineffective treatment by switching sooner
- Cost-Effective: Prevent spending on medications that won’t work for your mutation
- Peace of Mind: Understand exactly why treatment isn’t working and what to do next
- Better Outcomes: Get back on track with effective CML management faster
Understanding Your Results: Clear Guidance Every Step
We know waiting for results can be stressful. That’s why we provide:
- Clear Reports: Easy-to-understand results with plain language explanations
- Expert Interpretation: Your oncologist receives detailed analysis of what each mutation means
- Actionable Insights: Specific recommendations for treatment adjustments
- Ongoing Support: Results that integrate with your overall cancer care plan
Your results will clearly indicate which mutations are present and what treatment options are most likely to be effective based on international guidelines.
Transparent Pricing – Value That Makes Sense
| Service | Regular Price | Special Price | Savings |
|---|---|---|---|
| BCR-ABL1 Kinase Domain Mutation Analysis IRMA | ZAR 3,750 | ZAR 1,250 |
Turnaround Time: 7-8 days
Sample Required: Bone marrow or Peripheral blood (transport immediately)
Test Method: Sanger Sequencing – Gold standard accuracy
Note: This test requires a doctor’s prescription and is not applicable for surgery, pregnancy cases, or travel abroad purposes.
Why South Africans Trust Oracle Genomics
- Nationwide Coverage: Accessible testing across South Africa including major centres in Johannesburg, Cape Town, Durban, and Pretoria
- Medical Expertise: Specialised oncology testing with gynecologist oversight
- Accuracy Guarantee: Advanced Sanger Sequencing technology for reliable results
- Patient-Focused: Empathetic support throughout your testing journey
- Proven Track Record: Trusted by oncologists nationwide for genetic analysis
Take Control of Your CML Treatment Today
Don’t let treatment uncertainty control your life. Get the answers you need to make informed decisions about your cancer care.
Limited Time Offer: Save ZAR 1,250 on this essential analysis. Early detection of treatment resistance can make all the difference in your CML journey.
“Knowing why my treatment wasn’t working gave me back control of my health journey.” – Satisfied Patient

