Understanding Your Risk: PML/RARA Genetic Testing for AML-M3 Detection
When you’re experiencing symptoms that might indicate leukaemia, the uncertainty can be overwhelming. We understand the fear and anxiety that comes with potential blood cancer diagnosis. Our PML/RARA genetic test provides the clarity you need for Acute Promyelocytic Leukaemia (AML-M3), a specific subtype that requires precise identification for effective treatment.
What This Test Reveals About Your Health
The PML/RARA genetic test detects the specific chromosomal translocation that defines Acute Promyelocytic Leukaemia (AML-M3). This isn’t just another blood test – it’s a targeted genetic analysis that identifies the exact genetic abnormality responsible for this particular leukaemia subtype. Using Fluorescence In Situ Hybridization (FISH) technology, we examine your bone marrow or blood sample for the PML-RARA fusion gene, providing definitive answers about your condition.
When Should You Consider This Test?
If you’re experiencing unexplained symptoms like persistent fatigue, easy bruising, frequent infections, or abnormal bleeding, this test could provide critical answers. Particularly important for individuals with:
- Unexplained bleeding or bruising tendencies
- Persistent fatigue that doesn’t improve with rest
- Recurrent infections or fever without clear cause
- Abnormal blood counts detected in routine testing
- Family history of blood disorders or leukaemia
- Symptoms suggestive of acute leukaemia requiring specific subtype identification
Why Early Detection Matters for Your Health Journey
AML-M3 is unique among leukaemias because it responds exceptionally well to targeted therapies when identified early. Getting this specific genetic test means:
- Precise Diagnosis: Confirming AML-M3 enables targeted treatment rather than general approaches
- Treatment Guidance: Results directly influence therapy choices, potentially avoiding unnecessary treatments
- Peace of Mind: Knowing exactly what you’re dealing with reduces uncertainty and anxiety
- Better Outcomes: Early, accurate diagnosis leads to more effective treatment responses
- Family Planning: Understanding genetic factors helps in family health discussions
Understanding Your Results with Compassion
We know waiting for genetic test results can be stressful. Our team provides clear, understandable reports with expert guidance. Positive results mean the PML-RARA fusion gene is present, confirming AML-M3 diagnosis and opening doors to specific targeted therapies. Negative results provide reassurance and help your doctor explore other possibilities. Either way, you’ll have the information needed to move forward with confidence in your treatment plan.
Transparent Pricing for Your Peace of Mind
| Test Description | Regular Price | Special Price |
|---|---|---|
| PML/RARA Genetic Test (AML-M3) | ZAR 1,750 | |
| Includes comprehensive FISH analysis and expert interpretation | ||
Considering the potential cost of misdiagnosis or delayed treatment, this investment in precise genetic testing could save significantly on future healthcare expenses while providing life-changing diagnostic clarity.
Why South Africans Trust Oracle Genomics
With testing facilities across Johannesburg, Cape Town, Durban, and Pretoria, we bring expert genetic testing closer to home. Our specialised oncology team understands the unique concerns of South African patients and provides:
- Nationwide coverage with local sample collection points
- 3-4 day turnaround for rapid results
- Expert genetic counsellors available for result discussions
- Accredited laboratory standards ensuring result reliability
- Compassionate patient support throughout your testing journey
Take Control of Your Health Today
Don’t let uncertainty about potential leukaemia symptoms create unnecessary stress. Early, accurate genetic testing provides the answers you need for effective treatment planning. Our team is ready to support you through this important health decision.
Remember: Early detection through precise genetic testing can significantly improve treatment outcomes. Take the first step toward clarity and peace of mind today.

