Protect Yourself from Severe Allopurinol Reactions
Starting allopurinol for gout or kidney stones? This simple genetic test could prevent life-threatening skin reactions and organ damage. Many South African patients carry the HLA-B*58:01 gene that makes allopurinol treatment dangerous. Our test gives you the confidence to start treatment safely or explore alternative options.
Understanding Your HLA Hypersensitivity Test
Allopurinol is a common medication prescribed for gout and kidney stones, but for patients with the HLA-B*58:01 gene variant, it can trigger severe hypersensitivity reactions. Our test uses advanced PCR and sequencing technology to detect this specific genetic marker, helping your doctor make informed treatment decisions.
The test is simple and requires only a small blood sample or buccal swab. No special preparation is needed, and our nationwide network makes testing accessible across Johannesburg, Cape Town, Durban, and Pretoria.
Who Should Take This Test?
If you’re experiencing any of these situations, this test is essential for your safety:
- About to start allopurinol treatment for gout or elevated uric acid
- Family history of medication allergies or adverse reactions
- Previous sensitivity to other medications
- Concerned about potential severe skin reactions
- Wanting to ensure medication safety before treatment begins
Early detection can prevent conditions like Stevens-Johnson syndrome, toxic epidermal necrolysis, and drug rash with eosinophilia and systemic symptoms (DRESS).
Why This Test Matters for Your Health
Getting tested before starting allopurinol provides crucial benefits:
- Prevent Life-Threatening Reactions: Avoid severe skin conditions that can lead to hospitalization
- Personalized Treatment: Your doctor can choose the safest medication option for you
- Peace of Mind: Start treatment with confidence, knowing your genetic risk
- Cost Savings: Prevent expensive hospital stays and emergency treatments
- Better Health Outcomes: Ensure your treatment plan is both effective and safe
Understanding Your Test Results
Your results will clearly indicate whether you carry the HLA-B*58:01 gene variant:
- Positive Result: You have the gene variant and are at high risk for severe allopurinol reactions. Your doctor will recommend alternative treatments.
- Negative Result: You do not carry the gene variant and can proceed with allopurinol treatment with standard monitoring.
Our genetic counsellors are available to help you understand your results and discuss next steps with your healthcare provider.
Affordable Protection for Your Health
| Test Option | Regular Price | Special Price | Savings |
|---|---|---|---|
| HLA Hypersensitivity to Allopurinol Test | ZAR 2,700 | ZAR 1,300 |
Results delivered within 10-12 days | No hidden costs
Why Trust Oracle Genomics?
- Nationwide Coverage: Testing available across South Africa including Johannesburg, Cape Town, Durban, and Pretoria
- Medical Expertise: Specialized in nephrology and pharmacogenetic testing
- Advanced Technology: PCR and sequencing methods with 99.9% accuracy
- Quick Results: 10-12 day turnaround for timely treatment decisions
- Patient-Focused: Empathetic support throughout your testing journey
Take Control of Your Medication Safety Today
Don’t risk severe allergic reactions when starting allopurinol. This simple test provides the information you and your doctor need to make safe treatment decisions.
Limited time special pricing: Save ZAR 1,300 on this essential genetic safety test. Protect your health before starting treatment.

