Understanding Your Genetic Risk for Hereditary Spastic Paraplegia
If you or your family members experience progressive walking difficulties, muscle stiffness, or mobility challenges, you understand the uncertainty that comes with neurological symptoms. The CYP7B1 Gene SPG5A NGS Genetic DNA Test provides the clarity you need to understand your genetic predisposition to hereditary spastic paraplegia – a condition that affects thousands of South African families.
What This Test Reveals About Your Health
The CYP7B1 gene plays a crucial role in cholesterol metabolism in the brain and nervous system. When mutations occur in this gene, it can lead to SPG5A – a specific form of hereditary spastic paraplegia that typically begins in childhood or early adulthood. Our advanced Next-Generation Sequencing (NGS) technology examines your DNA with exceptional precision, identifying even the smallest genetic variations that could impact your neurological health.
This isn’t just another genetic test – it’s a comprehensive analysis that helps you understand your body’s unique blueprint and potential neurological risks.
Are You or Your Family Members at Risk?
This test is particularly important if you experience:
- Progressive difficulty walking or maintaining balance
- Muscle stiffness and spasms in your legs
- Family history of similar neurological symptoms
- Unexplained mobility challenges that began in childhood or young adulthood
- Concerns about passing genetic conditions to your children
Many South African patients describe feeling “stiff” or “uncoordinated” long before receiving a proper diagnosis. If this sounds familiar, genetic testing can provide the answers you’ve been seeking.
Why Early Detection Matters for Your Future
Knowing your genetic status empowers you to take control of your neurological health. Early detection of SPG5A allows for:
- Proactive Management: Implement physical therapy and lifestyle adjustments before symptoms progress
- Family Planning Confidence: Make informed decisions about starting a family with genetic counselling guidance
- Treatment Planning: Work with neurologists to develop personalised care strategies
- Peace of Mind: Reduce uncertainty and anxiety about your health future
- Early Intervention: Access supportive therapies that can improve quality of life
One Johannesburg family shared how genetic testing helped them understand three generations of mobility challenges, finally providing clarity and a path forward.
Understanding Your Test Results
We know waiting for genetic results can be anxiety-provoking. That’s why we provide clear, compassionate explanations of your findings:
- Positive Result: Indicates a CYP7B1 gene mutation associated with SPG5A. Our genetic counsellors will guide you through next steps and connect you with neurological specialists
- Negative Result: No SPG5A-associated mutations detected, providing reassurance about this specific condition
- Variant of Uncertain Significance: Rare genetic changes that require further evaluation – we’ll explain what this means for your health
Every result comes with a comprehensive consultation to ensure you fully understand the implications for your health and family.
Transparent Pricing – No Hidden Costs
| Service | Regular Price | Special Price | Value |
|---|---|---|---|
| CYP7B1 SPG5A Genetic Test | ZAR 6,700 | Save ZAR 2,650 | |
| Genetic Counselling Session | INCLUDED (ZAR 1,200 value) | ||
| Family Pedigree Analysis | INCLUDED | ||
| Neurologist Consultation Support | INCLUDED | ||
Consider the long-term value: Early detection could save thousands in future medical costs and preserve your quality of life.
Why South Africans Trust Oracle Genomics
- Nationwide Coverage: Accessible testing centres in Johannesburg, Cape Town, Durban, Pretoria and across South Africa
- Expert Genetic Counselling: Every test includes professional guidance to help you understand your results
- Advanced NGS Technology: State-of-the-art genetic sequencing for maximum accuracy
- Quick Turnaround: Results within 3-4 weeks – faster than many international labs
- Multiple Sample Options: Blood, extracted DNA, or simple FTA card blood spot collection
- Neurology Specialisation: Tests designed and interpreted by neurological genetics experts
Take the First Step Toward Genetic Clarity
Don’t let uncertainty about hereditary spastic paraplegia control your future. Our compassionate team is ready to guide you through this important health decision.
Limited Time Offer: Save ZAR 2,650 on comprehensive genetic testing including professional counselling. Early detection could significantly impact your quality of life and family planning decisions.
Convenient Sample Collection: Choose from blood draw, DNA extraction, or simple finger-prick blood spot – we make genetic testing accessible for every South African.
Your genetic journey begins with a single step. Let us walk with you toward clarity, confidence, and control over your neurological health.
