Find Clarity for Complex Skin and Immune Conditions
Living with unexplained skin inflammation, thickened palms and soles, or recurrent infections can feel overwhelming and isolating. When traditional treatments don’t provide answers, genetic testing offers the clarity you deserve. Our DSG1 Gene NGS Test is specifically designed to identify the genetic root cause of congenital erythroderma with palmoplantar keratoderma, hypotrichosis, and hyper IgE syndrome – giving you and your family definitive answers after years of uncertainty.
Understanding Your DSG1 Genetic Test
This specialised Next Generation Sequencing (NGS) test examines your DSG1 gene for specific mutations that disrupt normal skin and immune function. The DSG1 gene produces desmoglein-1, a crucial protein that helps skin cells stick together properly. When this gene contains mutations, it can lead to the characteristic symptoms of widespread skin inflammation (erythroderma), thickened skin on palms and soles (palmoplantar keratoderma), sparse hair (hypotrichosis), and elevated IgE levels causing recurrent infections.
Our advanced NGS technology provides comprehensive analysis of the entire DSG1 gene, ensuring no mutation goes undetected. This level of precision means you receive accurate, reliable results that can guide appropriate treatment and management strategies.
Who Should Consider This Genetic Test?
This test is particularly important if you or your child experience:
- Widespread red, inflamed skin present from birth or early infancy
- Thickened, scaly skin on palms and soles that interferes with daily activities
- Noticeably sparse hair growth or hair loss
- Frequent skin infections, respiratory infections, or allergic reactions
- Family history of similar skin and immune conditions
- Previous inconclusive diagnostic tests for skin disorders
Many South African families have spent years seeking answers for these complex symptoms. Our genetic test provides the definitive diagnosis needed to move forward with confidence.
Why Early Genetic Diagnosis Matters for Your Health
Receiving a precise genetic diagnosis transforms your healthcare journey from uncertainty to empowerment. With confirmed DSG1 gene mutations, you can:
- Access Targeted Treatments: Work with dermatologists to develop personalised management plans
- Prevent Complications: Implement proactive strategies to reduce infection risks and skin damage
- Make Informed Family Planning Decisions: Understand inheritance patterns and recurrence risks
- Connect with Support Networks: Join communities of families facing similar challenges
- Reduce Healthcare Costs: Avoid unnecessary tests and ineffective treatments
Early diagnosis means earlier intervention, potentially preventing years of discomfort and complications.
Understanding Your Test Results
We understand that waiting for genetic results can be anxiety-provoking. That’s why we include comprehensive genetic counselling with every test. Your results will clearly indicate:
- Positive Result: Specific DSG1 gene mutations identified, confirming the diagnosis
- Negative Result: No DSG1 mutations detected, suggesting other causes for symptoms
- Variant of Uncertain Significance: Genetic changes found, but their clinical significance requires further evaluation
Regardless of your results, our genetic counsellors will help you understand what they mean for your health and guide you toward appropriate next steps. You’re never alone in this process.
Transparent Pricing – Exceptional Value
| Service | Regular Price | Special Price | Savings |
|---|---|---|---|
| DSG1 Gene NGS Test | ZAR 9,350 | ZAR 6,700 | ZAR 2,650 |
| Includes: Genetic testing, comprehensive analysis, genetic counselling session, and detailed results report | |||
Consider this investment in your health: the cost of ongoing specialist visits, multiple tests, and ineffective treatments often far exceeds the one-time investment in definitive genetic testing.
Why Trust Oracle Genomics?
We’ve built our reputation on accuracy, empathy, and accessibility across South Africa:
- Nationwide Coverage: Available in Johannesburg, Cape Town, Durban, Pretoria and throughout South Africa
- Medical Expertise: Tests supervised by qualified dermatologists and genetic specialists
- Advanced Technology: State-of-the-art NGS equipment ensuring 99.9% accuracy
- Patient-Centred Care: Empathetic support throughout your testing journey
- Rapid Turnaround: Results typically within 3-4 weeks
Thousands of South African families have trusted us with their genetic health concerns – join them in finding the answers you deserve.
Take the First Step Toward Clarity Today
Don’t let uncertainty about your or your child’s health continue. Our simple testing process begins with:
- Sample Collection: Simple blood draw or FTA card sample at any of our nationwide locations
- Genetic Counselling: Comprehensive session to understand your family history and concerns
- Advanced Analysis: Our laboratory team performs detailed NGS testing
- Clear Results: Receive your comprehensive report with expert interpretation
Book your DSG1 Genetic Test now at our special price of ZAR 6,700 and take control of your health journey. Limited appointments available at this discounted rate.
Take advantage of our special pricing while available. Your path to answers and appropriate care starts here.
