Imatinib Resistance Mutation Analysis (IRMA) Test

R3,400

The Imatinib Resistance Mutation Analysis (IRMA) test is your crucial defence against treatment resistance in chronic myeloid leukaemia (CML). For just ZAR 3,500, this advanced genetic test detects mutations that may cause your imatinib treatment to stop working effectively. When you notice your CML symptoms returning or your blood counts changing despite medication, this test provides the answers you need. Our state-of-the-art PCR and sequencing technology delivers 99.9% accurate results within 5 days, giving you and your oncologist the clarity to adjust your treatment plan promptly. Trust Oracle Genomics’ nationwide network across Johannesburg, Cape Town, Durban and Pretoria for this life-changing analysis. Early detection of resistance can make all the difference in managing your CML successfully and maintaining your quality of life.

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  • ✓ ISO Accredited Lab Reports
  • ✓ Free Genetic Counseling Included
  • 🔒 100% Confidential & Secure Testing
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IRMA Test ZAR 3
Imatinib Resistance Mutation Analysis (IRMA) Test
R3,400

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Take Control of Your CML Treatment Journey

Living with chronic myeloid leukaemia (CML) brings enough challenges without worrying whether your treatment is still working. When you’ve been faithfully taking your imatinib medication but notice concerning changes in your health, the uncertainty can be overwhelming. The IRMA test provides the clarity and confidence you deserve in your treatment journey.

Understanding Your IRMA Test

The Imatinib Resistance Mutation Analysis (IRMA) test is a sophisticated genetic examination that specifically looks for mutations in the BCR-ABL gene that may cause resistance to imatinib treatment. Think of it as a precision tool that helps your oncologist understand exactly why your current treatment might not be working as effectively as before.

Using advanced PCR and sequencing technology, our laboratory experts analyse your blood sample to identify specific genetic changes that could be compromising your treatment’s effectiveness. This isn’t just another blood test – it’s a targeted investigation into the very mechanisms of your CML.

Who Should Consider This Essential Test?

If you’re experiencing any of these concerning signs, the IRMA test could provide critical answers:

  • Your blood counts are no longer responding as expected to imatinib treatment
  • You’ve noticed a return of CML symptoms like fatigue, night sweats, or abdominal discomfort
  • Your latest BCR-ABL quantitative results show concerning trends
  • Your oncologist has expressed concerns about treatment response
  • You’re preparing for a potential treatment change and need definitive information

Many patients tell us they waited too long before investigating treatment resistance. Don’t let uncertainty compromise your health – early detection gives you the best chance for successful treatment adjustment.

Why This Test Matters for Your Health Journey

Getting your IRMA test done provides multiple life-changing benefits:

  • Treatment Clarity: Understand exactly why your current medication may not be working optimally
  • Timely Intervention: Catch resistance early before it significantly impacts your health
  • Personalised Care: Enable your oncologist to tailor your treatment plan based on precise genetic information
  • Peace of Mind: Replace uncertainty with clear, actionable information about your treatment path
  • Better Outcomes: Early detection of resistance leads to more successful treatment adjustments and improved quality of life

Understanding Your Results – We’re Here to Guide You

Receiving your IRMA test results can feel daunting, but we’re committed to making the process as clear and reassuring as possible. Your comprehensive report will clearly indicate whether resistance mutations were detected and provide detailed information about specific genetic changes.

Most importantly, your results come with guidance for discussing them with your oncologist. We provide clear explanations in language you can understand, helping you prepare for your next medical appointment with confidence.

Remember: A positive result for resistance mutations isn’t bad news – it’s valuable information that empowers you and your doctor to make informed decisions about your treatment future.

Transparent Pricing – Your Health Investment

Service Price Value
IRMA Test Regular Price ZAR 3,400 Comprehensive genetic analysis
Special Offer Price ZAR 3,500 Includes expert interpretation
Turnaround Time 5 Days Sample Monday by 11 AM, Report Saturday

Consider this: The cost of delayed treatment adjustment due to undetected resistance can far exceed the investment in this test. Early detection saves not only money but, more importantly, preserves your health and treatment effectiveness.

Why Thousands of South Africans Trust Oracle Genomics

We understand that genetic testing requires absolute confidence in your laboratory. Here’s why patients across South Africa choose us:

  • Nationwide Coverage: Convenient testing available in Johannesburg, Cape Town, Durban, Pretoria and throughout South Africa
  • Medical Expertise: Our tests are developed and interpreted by specialist oncologists and genetic experts
  • Accuracy Guarantee: 99.9% accuracy rate through advanced PCR and sequencing technology
  • Patient-First Approach: We prioritise your comfort, understanding, and peace of mind throughout the process
  • Rapid Results: Get your comprehensive report within 5 days to inform timely treatment decisions

Simple Sample Collection Process

We’ve made the testing process as straightforward as possible:

  • Sample Required: 4 mL (2 mL minimum) whole blood in 1 Lavender Top (EDTA) tube
  • Shipping: Ship refrigerated – DO NOT FREEZE
  • Essential: Submit your latest BCR-ABL Quantitative report along with your sample
  • Timing: Submit samples by Monday 11 AM for Saturday results

Our nationwide network makes sample collection convenient wherever you are in South Africa.

Take the Next Step in Your CML Journey

Don’t let treatment uncertainty control your life. Every day you wait could mean missed opportunities for optimising your treatment plan.

Book your IRMA test today for ZAR 3,500 and gain the clarity you need to move forward with confidence.

Our team is ready to help you schedule your test at a location convenient for you in Johannesburg, Cape Town, Durban, Pretoria or anywhere in South Africa. Take control of your treatment journey – your future self will thank you.



Early detection of treatment resistance can significantly improve your CML management outcomes. Don’t wait until your next routine check-up – proactive testing gives you the advantage.