Understanding Your Risk for Hereditary Esophageal Cancer
If you’ve noticed thickened skin on your palms and soles (tylosis) or have a family history of esophageal cancer, you may be carrying the RHBDF2 gene mutation. This isn’t just about skin changes – it’s about understanding your lifetime risk for developing esophageal cancer, which can be as high as 95% for those with this genetic condition. Many South Africans live with this uncertainty, but now you can get definitive answers and take proactive steps to protect your health.
What This Test Detects
The RHBDF2 Gene Test uses Next Generation Sequencing (NGS) technology to identify specific mutations in your RHBDF2 gene. This gene, when mutated, causes tylosis with esophageal cancer syndrome – a rare but serious hereditary condition where thickened skin on palms and soles (tylosis) serves as an early warning sign for significantly increased esophageal cancer risk. Our test doesn’t just look for one mutation; it comprehensively analyses the entire RHBDF2 gene to provide the most accurate results possible.
Who Should Consider This Test
This test is particularly important if you experience:
- Thickened skin on your palms or soles (tylosis) that appeared in childhood or early adulthood
- A family history of esophageal cancer, especially in multiple relatives
- Both tylosis and family history of esophageal cancer
- Unexplained difficulty swallowing or other esophageal symptoms with family history
- Planning to start a family and concerned about passing on genetic risks
Why Early Detection Matters for Your Health
Knowing your RHBDF2 status transforms uncertainty into actionable knowledge. If you test positive, you can begin regular esophageal cancer screening much earlier than the general population, dramatically improving your chances of detecting any abnormalities at their most treatable stages. Many patients find immense relief in having a clear health management plan rather than living with constant worry. Early detection through genetic testing has helped countless families break the cycle of hereditary cancer.
Understanding Your Results with Compassion
We understand that genetic testing can be anxiety-provoking. That’s why every test includes professional genetic counselling to help you understand your results in the context of your personal and family health history. Our genetic counsellors will explain what your results mean for your health management, discuss screening recommendations, and provide emotional support throughout the process. Whether your results are positive or negative, you’ll leave with a clear understanding of your next steps.
Transparent Pricing and Value
| Service | Price |
|---|---|
| Regular Price | ZAR 9,350 |
| Special Price | ZAR 6,700 |
| Genetic Counselling Session | Included |
| Family Pedigree Analysis | Included |
| Turnaround Time | 3-4 Weeks |
Consider this: the cost of comprehensive esophageal cancer treatment can exceed ZAR 500,000. Our test at ZAR 6,700 represents a small investment that could save both money and, more importantly, lives through early detection and prevention.
Nationwide Trust and Accessibility
Oracle Genomics brings world-class genetic testing to every corner of South Africa. We have trusted collection centres in Johannesburg, Cape Town, Durban, Pretoria, and major cities nationwide. Our NGS technology meets international standards for accuracy, and our team includes experienced genetic counsellors who understand the unique healthcare landscape in South Africa. We’ve helped thousands of South African families gain clarity about their genetic health.
Take Control of Your Genetic Health Today
Don’t let uncertainty about hereditary cancer risk control your life. Our RHBDF2 Gene Test provides the answers you need to make informed decisions about your health future. With convenient testing locations across South Africa and comprehensive support throughout your journey, there’s never been a better time to take this important step.
Book your test today and begin your journey toward genetic clarity and peace of mind. Call us now or visit our website to schedule your genetic counselling session and testing appointment. Your future health deserves this level of attention and care.
